Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome
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Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome. / Muñoz-Prieto, Alberto; Cerón, José J.; Rubio, Camila P.; Contreras-Aguilar, María Dolores; Pardo-Marín, Luis; Ayala-de la Peña, Ignacio; Martín-Cuervo, María; Holm Henriksen, Ida Marie; Arense-Gonzalo, Julián J.; Tecles, Fernando; Hansen, Sanni.
I: Animals, Bind 12, Nr. 23, 3261, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome
AU - Muñoz-Prieto, Alberto
AU - Cerón, José J.
AU - Rubio, Camila P.
AU - Contreras-Aguilar, María Dolores
AU - Pardo-Marín, Luis
AU - Ayala-de la Peña, Ignacio
AU - Martín-Cuervo, María
AU - Holm Henriksen, Ida Marie
AU - Arense-Gonzalo, Julián J.
AU - Tecles, Fernando
AU - Hansen, Sanni
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2022
Y1 - 2022
N2 - In this report, the measurement of salivary biomarkers as an aid for diagnosis of equine gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was measured in the saliva of horses affected by EGUS and compared to healthy animals and horses with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination. A total of 147 horses were included in the study and divided into heathy population (n = 12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23 analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to the group of other diseases. The receiver operating characteristic curve analyses showed a modest but significant discriminatory power of those three analytes to identify EGUS from other diseases with similar symptoms. The discriminatory power enhanced when the results of the three analytes were combined. In conclusion, the results showed that selected salivary analytes could have potential use as biomarkers in horses with EGUS.
AB - In this report, the measurement of salivary biomarkers as an aid for diagnosis of equine gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was measured in the saliva of horses affected by EGUS and compared to healthy animals and horses with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination. A total of 147 horses were included in the study and divided into heathy population (n = 12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23 analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to the group of other diseases. The receiver operating characteristic curve analyses showed a modest but significant discriminatory power of those three analytes to identify EGUS from other diseases with similar symptoms. The discriminatory power enhanced when the results of the three analytes were combined. In conclusion, the results showed that selected salivary analytes could have potential use as biomarkers in horses with EGUS.
KW - biomarkers
KW - diagnosis
KW - equine gastric ulcer syndrome
KW - horse
KW - saliva
U2 - 10.3390/ani12233261
DO - 10.3390/ani12233261
M3 - Journal article
C2 - 36496782
AN - SCOPUS:85143600221
VL - 12
JO - Animals
JF - Animals
SN - 2076-2615
IS - 23
M1 - 3261
ER -
ID: 330935663