Long-Term Training Increases Atrial Fibrillation Sustainability in Standardbred Racehorses
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Long-Term Training Increases Atrial Fibrillation Sustainability in Standardbred Racehorses. / Carstensen, Helena; Nissen, Sarah Dalgas; Saljic, Arnela; Hesselkilde, Eva Melis; van Hunnik, Arne; Hohl, Mathias; Sattler, Stefan Michael; Fløgstad, Cecilie; Hopster-Iversen, Charlotte; Verheule, Sander; Böhm, Michael; Schotten, Ulrich; Jespersen, Thomas; Buhl, Rikke.
I: Journal of Cardiovascular Translational Research, Bind 16, 2023, s. 1205–1219.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-Term Training Increases Atrial Fibrillation Sustainability in Standardbred Racehorses
AU - Carstensen, Helena
AU - Nissen, Sarah Dalgas
AU - Saljic, Arnela
AU - Hesselkilde, Eva Melis
AU - van Hunnik, Arne
AU - Hohl, Mathias
AU - Sattler, Stefan Michael
AU - Fløgstad, Cecilie
AU - Hopster-Iversen, Charlotte
AU - Verheule, Sander
AU - Böhm, Michael
AU - Schotten, Ulrich
AU - Jespersen, Thomas
AU - Buhl, Rikke
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Atrial fibrillation (AF) is more prevalent in athletes, and currently, the mechanisms are not fully understood. Atrial fibrillation inducibility and stability was investigated in trained and untrained Standardbred racehorses. The horses underwent echocardiography for evaluation of atrial size. High-density mapping during AF was performed, and the presence of structural remodeling, as well as the expression of inflammatory and pro-inflammatory markers in the atria, was studied. Atrial fibrillation sustained significantly longer after tachypacing in the trained horses, whereas no difference in AF inducibility was found. The untrained horses displayed a significant difference in the AF complexity when comparing right and left atria, whereas such difference was not observed in the trained animals. No evidence of increased structural remodeling or inflammation could be identified. Left atrial dimensions were not significantly increased. The increased AF sustainability in trained horses was not related to fibrosis or inflammation as seen in other animal exercise models. Graphical abstract: [Figure not available: see fulltext.].
AB - Atrial fibrillation (AF) is more prevalent in athletes, and currently, the mechanisms are not fully understood. Atrial fibrillation inducibility and stability was investigated in trained and untrained Standardbred racehorses. The horses underwent echocardiography for evaluation of atrial size. High-density mapping during AF was performed, and the presence of structural remodeling, as well as the expression of inflammatory and pro-inflammatory markers in the atria, was studied. Atrial fibrillation sustained significantly longer after tachypacing in the trained horses, whereas no difference in AF inducibility was found. The untrained horses displayed a significant difference in the AF complexity when comparing right and left atria, whereas such difference was not observed in the trained animals. No evidence of increased structural remodeling or inflammation could be identified. Left atrial dimensions were not significantly increased. The increased AF sustainability in trained horses was not related to fibrosis or inflammation as seen in other animal exercise models. Graphical abstract: [Figure not available: see fulltext.].
KW - Athlete’s heart
KW - Atrial fibrillation
KW - Cardiac remodeling
KW - Epicardial mapping
KW - Exercise
KW - Inflammation
U2 - 10.1007/s12265-023-10378-6
DO - 10.1007/s12265-023-10378-6
M3 - Journal article
C2 - 37014465
AN - SCOPUS:85151529578
VL - 16
SP - 1205
EP - 1219
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
SN - 1937-5387
ER -
ID: 343340888