Survival rates and factors associated with survival and laminitis of horses with acute diarrhoea admitted to referral institutions
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Survival rates and factors associated with survival and laminitis of horses with acute diarrhoea admitted to referral institutions. / Gomez, Diego E.; Dunkel, Bettina; Renaud, David L.; Arroyo, Luis G.; Schoster, Angelika; Kopper, Jamie J.; Byrne, David; The Multicenter Equine Diarrhea (MEDS) group; Toribio, Ramiro E.; Pihl, Tina H. (Medlem af forfattergruppering).
I: Equine Veterinary Journal, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Survival rates and factors associated with survival and laminitis of horses with acute diarrhoea admitted to referral institutions
AU - Gomez, Diego E.
AU - Dunkel, Bettina
AU - Renaud, David L.
AU - Arroyo, Luis G.
AU - Schoster, Angelika
AU - Kopper, Jamie J.
AU - Byrne, David
AU - The Multicenter Equine Diarrhea (MEDS) group
AU - Toribio, Ramiro E.
A2 - Pihl, Tina H.
N1 - Publisher Copyright: © 2023 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.
PY - 2024
Y1 - 2024
N2 - BackgroundClinicopathological findings and their association with the outcome and development of laminitis in horses with acute diarrhoea has not been investigated in a multicentre study across different geographic regions.ObjectivesDescribe and compare clinicopathologic findings of diarrhoeic horses between different geographic regions, survival rates and factors associated with non-survival and laminitis.Study designMulticentre retrospective case series.MethodsInformation from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020 was collected, and clinicopathological data were compared between surviving and non-surviving horses and horses that did and did not develop laminitis. Survival rates and seasonal and geographic differences were also investigated.ResultsOne thousand four hundred thirty-eight horses from 26 participating institutions from 4 continents were included; 76% survived to discharge with no differences identified between geographic regions. The survival proportion of horses with SIRS and creatinine concentrations > 159 μmol/L was 55% (154/279) compared with 81% (358/437) for those with SIRS and creatinine concentrations < 159 μmol/L (p < 0.001). The survival proportion of horses with SIRS that had an L-lactate concentration > 2.8 mmol/L was 59% (175/298) compared with 81% (240/296) in horses with SIRS and L-lactate concentration < 2.8 mmol/L (p < 0.001). The proportion of horses that developed laminitis was lower in Europe (4%, 19/479) compared with North America (8%, 52/619), Australia (8%, 12/138) and Latin America (11%, 16/146) (p < 0.05). More horses developed laminitis in the summer (46%, 39/85) compared with winter (18%, 15/85), spring (18%, 15/85) and fall (19%, 16/85) (p < 0.01). Horses with laminitis had greater odds of non-survival than those without laminitis (OR: 3.73, 95% CI: 2.47–5.65).Main limitationsNot all variables were available for all horses due to the retrospective nature.Conclusions Clinicopathological findings in horses with acute diarrhoea and their association with survival are similar across geographic regions. However, developing laminitis secondary to diarrhoea is less common in Europe. In addition, factors associated with non-survival were indicative of disease severity and subsequent cardiovascular compromise.
AB - BackgroundClinicopathological findings and their association with the outcome and development of laminitis in horses with acute diarrhoea has not been investigated in a multicentre study across different geographic regions.ObjectivesDescribe and compare clinicopathologic findings of diarrhoeic horses between different geographic regions, survival rates and factors associated with non-survival and laminitis.Study designMulticentre retrospective case series.MethodsInformation from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020 was collected, and clinicopathological data were compared between surviving and non-surviving horses and horses that did and did not develop laminitis. Survival rates and seasonal and geographic differences were also investigated.ResultsOne thousand four hundred thirty-eight horses from 26 participating institutions from 4 continents were included; 76% survived to discharge with no differences identified between geographic regions. The survival proportion of horses with SIRS and creatinine concentrations > 159 μmol/L was 55% (154/279) compared with 81% (358/437) for those with SIRS and creatinine concentrations < 159 μmol/L (p < 0.001). The survival proportion of horses with SIRS that had an L-lactate concentration > 2.8 mmol/L was 59% (175/298) compared with 81% (240/296) in horses with SIRS and L-lactate concentration < 2.8 mmol/L (p < 0.001). The proportion of horses that developed laminitis was lower in Europe (4%, 19/479) compared with North America (8%, 52/619), Australia (8%, 12/138) and Latin America (11%, 16/146) (p < 0.05). More horses developed laminitis in the summer (46%, 39/85) compared with winter (18%, 15/85), spring (18%, 15/85) and fall (19%, 16/85) (p < 0.01). Horses with laminitis had greater odds of non-survival than those without laminitis (OR: 3.73, 95% CI: 2.47–5.65).Main limitationsNot all variables were available for all horses due to the retrospective nature.Conclusions Clinicopathological findings in horses with acute diarrhoea and their association with survival are similar across geographic regions. However, developing laminitis secondary to diarrhoea is less common in Europe. In addition, factors associated with non-survival were indicative of disease severity and subsequent cardiovascular compromise.
KW - antimicrobial associated diarrhoea
KW - Clostridiosis
KW - horse
KW - Potomac horse fever
KW - sand diarrhoea
U2 - 10.1111/evj.14032
DO - 10.1111/evj.14032
M3 - Journal article
C2 - 38083907
JO - Equine Veterinary Journal
JF - Equine Veterinary Journal
SN - 0425-1644
ER -
ID: 384344454