Temporal and concentration effects of isoflurane anaesthesia on intestinal tissue oxygenation and perfusion in horses
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Temporal and concentration effects of isoflurane anaesthesia on intestinal tissue oxygenation and perfusion in horses. / Hopster, K.; Hopster-Iversen, C.; Geburek, F.; Rohn, K.; Kaestner, S. B. R.
I: Veterinary Journal, Bind 205, Nr. 1, 07.2015, s. 62-68.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Temporal and concentration effects of isoflurane anaesthesia on intestinal tissue oxygenation and perfusion in horses
AU - Hopster, K.
AU - Hopster-Iversen, C.
AU - Geburek, F.
AU - Rohn, K.
AU - Kaestner, S. B. R.
PY - 2015/7
Y1 - 2015/7
N2 - The aim of this study was to assess the effect of duration of anaesthesia and concentration of isoflurane on global perfusion as well as intestinal microperfusion and oxygenation. Nine Warmblood horses were premedicated with xylazine; anaesthesia was induced with midazolam and ketamine, and maintained with isoflurane. Horses were ventilated to normocapnia. During 7 h of anaesthesia, mean arterial blood pressures (MAP), heart rate, central venous pressure, pulmonary artery pressure, expiratory isoflurane concentration (E(T)Iso) and cardiac output using lithium dilution were measured; cardiac index (CI) was calculated. Intestinal microperfusion and oxygenation were measured using laser Doppler flowmetry and white-light spectrophotometry. Surface probes were placed via median laparotomy on the serosal and mucosal site of the jejunum and the pelvic flexion of the colon.After 3 h of constant E(T)Iso (1.4%), E(T)Iso was increased in 0.2% increments up to 2.4%, followed by a decrease to 1.2% and an increase to 1.4%. The Cl and MAP decreased continuously with increasing ETIso to 40 +/- 5 mL/kg/min and 52 +/- 8 mmHg, respectively. Microperfusion and oxygenation remained unchanged until an ETIso of 2.0% resulted in CI and MAP of 48 +/- 5 mL/kg/min and 62 +/- 6 mmHg, respectively, and then decreased rapidly. When E(T)Iso decreased back to baseline, Cl, MAP, microperfusion and oxygenation recovered to baseline. Isoflurane concentration but not duration of isoflurane anaesthesia influenced central and intestinal oxygenation and perfusion in healthy horses. Under isoflurane, intestinal perfusion appeared to be preserved until a threshold MAP or blood flow was reached. (C) 2015 Elsevier Ltd. All rights reserved.
AB - The aim of this study was to assess the effect of duration of anaesthesia and concentration of isoflurane on global perfusion as well as intestinal microperfusion and oxygenation. Nine Warmblood horses were premedicated with xylazine; anaesthesia was induced with midazolam and ketamine, and maintained with isoflurane. Horses were ventilated to normocapnia. During 7 h of anaesthesia, mean arterial blood pressures (MAP), heart rate, central venous pressure, pulmonary artery pressure, expiratory isoflurane concentration (E(T)Iso) and cardiac output using lithium dilution were measured; cardiac index (CI) was calculated. Intestinal microperfusion and oxygenation were measured using laser Doppler flowmetry and white-light spectrophotometry. Surface probes were placed via median laparotomy on the serosal and mucosal site of the jejunum and the pelvic flexion of the colon.After 3 h of constant E(T)Iso (1.4%), E(T)Iso was increased in 0.2% increments up to 2.4%, followed by a decrease to 1.2% and an increase to 1.4%. The Cl and MAP decreased continuously with increasing ETIso to 40 +/- 5 mL/kg/min and 52 +/- 8 mmHg, respectively. Microperfusion and oxygenation remained unchanged until an ETIso of 2.0% resulted in CI and MAP of 48 +/- 5 mL/kg/min and 62 +/- 6 mmHg, respectively, and then decreased rapidly. When E(T)Iso decreased back to baseline, Cl, MAP, microperfusion and oxygenation recovered to baseline. Isoflurane concentration but not duration of isoflurane anaesthesia influenced central and intestinal oxygenation and perfusion in healthy horses. Under isoflurane, intestinal perfusion appeared to be preserved until a threshold MAP or blood flow was reached. (C) 2015 Elsevier Ltd. All rights reserved.
KW - Gastrointestinal tract
KW - Laser Doppler flowmetry
KW - Microperfusion
KW - White-light spectrophotometry
KW - HALOTHANE ANESTHESIA
KW - BLOOD-FLOW
KW - MICROCIRCULATION
KW - METABOLISM
KW - AWAKE
U2 - 10.1016/j.tvjl.2015.04.030
DO - 10.1016/j.tvjl.2015.04.030
M3 - Journal article
VL - 205
SP - 62
EP - 68
JO - The Veterinary Journal
JF - The Veterinary Journal
SN - 1090-0233
IS - 1
ER -
ID: 258097991